The cytoplasmic fate of an mRNP is determined cotranscriptionally: Exception or rule?

Tatjana Trcek; Robert H. Singer

doi:10.1101/gad.1972810

The cytoplasmic fate of an mRNP is determined cotranscriptionally: Exception or rule?

Tatjana Trcek, Robert H. Singer

Cell Biology

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

Original language	English (US)
Pages (from-to)	1827-1831
Number of pages	5
Journal	Genes and Development
Volume	24
Issue number	17
DOIs	https://doi.org/10.1101/gad.1972810
State	Published - Sep 1 2010

Keywords

Cotranscriptional
Localization
She2p
Spt4p
Spt5p
Yeast
mRNA

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1972810

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title = "The cytoplasmic fate of an mRNP is determined cotranscriptionally: Exception or rule?",

abstract = "She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.",

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T2 - Exception or rule?

AU - Trcek, Tatjana

AU - Singer, Robert H.

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Y1 - 2010/9/1

N2 - She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

AB - She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

KW - Cotranscriptional

KW - Localization

KW - She2p

KW - Spt4p

KW - Spt5p

KW - Yeast

KW - mRNA

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M3 - Review article

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JO - Genes and Development

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ER -

The cytoplasmic fate of an mRNP is determined cotranscriptionally: Exception or rule?

Abstract

Keywords

ASJC Scopus subject areas

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