The chemical biology of new drugs in the development for tuberculosis

Clifton E. Barry, John S. Blanchard

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains.

Original languageEnglish (US)
Pages (from-to)456-466
Number of pages11
JournalCurrent Opinion in Chemical Biology
Issue number4
StatePublished - Aug 2010
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


Dive into the research topics of 'The chemical biology of new drugs in the development for tuberculosis'. Together they form a unique fingerprint.

Cite this