The CD1 family of lipid antigen-presenting molecules

Steven A. Porcelli, Brent W. Segelke, Masahiko Sugita, Ian A. Wilson, Michael B. Brenner

Research output: Contribution to journalReview articlepeer-review

151 Scopus citations


The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

Original languageEnglish (US)
Pages (from-to)362-368
Number of pages7
JournalImmunology today
Issue number8
StatePublished - Aug 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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