The CD1 family of lipid antigen-presenting molecules

Steven A. Porcelli; Brent W. Segelke; Masahiko Sugita; Ian A. Wilson; Michael B. Brenner

doi:10.1016/S0167-5699(98)01289-4

The CD1 family of lipid antigen-presenting molecules

Steven A. Porcelli, Brent W. Segelke, Masahiko Sugita, Ian A. Wilson, Michael B. Brenner

Research output: Contribution to journal › Review article › peer-review

151 Scopus citations

Abstract

The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

Original language	English (US)
Pages (from-to)	362-368
Number of pages	7
Journal	Immunology today
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/S0167-5699(98)01289-4
State	Published - Aug 1 1998
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/S0167-5699(98)01289-4

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title = "The CD1 family of lipid antigen-presenting molecules",

abstract = "The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.",

author = "Porcelli, {Steven A.} and Segelke, {Brent W.} and Masahiko Sugita and Wilson, {Ian A.} and Brenner, {Michael B.}",

note = "Funding Information: The authors thank D. Branch Moody for assistance with the figures and for helpful discussions. This work was supported in part by NIH grants AI40135 (S.P.), CA58896 (I.A.W.), AI28973 and AR39502 (M.B.B.), and also by grants from the Arthritis Foundation (S.P., Investigator Award; M.S., Postdoctoral Fellowship Award) and the American Cancer Society (S.P.).",

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T1 - The CD1 family of lipid antigen-presenting molecules

AU - Porcelli, Steven A.

AU - Segelke, Brent W.

AU - Sugita, Masahiko

AU - Wilson, Ian A.

AU - Brenner, Michael B.

N1 - Funding Information: The authors thank D. Branch Moody for assistance with the figures and for helpful discussions. This work was supported in part by NIH grants AI40135 (S.P.), CA58896 (I.A.W.), AI28973 and AR39502 (M.B.B.), and also by grants from the Arthritis Foundation (S.P., Investigator Award; M.S., Postdoctoral Fellowship Award) and the American Cancer Society (S.P.).

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Y1 - 1998/8/1

N2 - The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

AB - The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

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The CD1 family of lipid antigen-presenting molecules

Abstract

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