TY - JOUR
T1 - The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy
AU - Naji, Leen
AU - Dennis, Brittany Burns
AU - Bawor, Monica
AU - Varenbut, Michael
AU - Daiter, Jeff
AU - Plater, Carolyn
AU - Pare, Guillaume
AU - Marsh, David C.
AU - Worster, Andrew
AU - Desai, Dipika
AU - MacKillop, James
AU - Thabane, Lehana
AU - Samaan, Zainab
N1 - Funding Information:
This work was funded by the Canadian Institutes for Health Research (CIHR) Drug Safety and Effectiveness Network grant (Grant Number: 126639). Brittany B. Dennis and Monica Bawor are supported by the Intersections of Mental Health Perspectives in Addiction Research Training fellowship, supported by CIHR and the British Columbia Centre of Excellence for Women’s Health. This work was also supported by the Peter Boris Centre for Addiction Research and Chanchlani Research Centre. The funders had no role in the design or execution of the study, collection or analysis of the data, and preparation or review of the manuscript.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/19
Y1 - 2017/12/19
N2 - Background: Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this association may inform clinical practice about important prognostic factors of patients on MMT, enabling clinicians to identify high-risk patients. Methods: This study includes data collected between June 2011 and August 2016 for the Genetics of Opioid Addiction research collaborative between McMaster University and the Canadian Addiction Treatment Centers. All patients were interviewed by trained health professionals using the Mini-International Neuropsychiatric Interview and case report forms. Physical comorbidities were verified using patients' electronic medical records. A multi-variable logistic regression model was constructed to determine the strength of the association between age of onset of opioid use and the presence of physical or psychiatric comorbidity while adjusting for current age, sex, body mass index, methadone dose and smoking status. Results: Data from 627 MMT patients with a mean age of 38.8 years (SD = 11.07) were analyzed. Individuals with an age of onset of opioid use younger than 18 years were found to be at higher odds for having a physical or psychiatric comorbid disorder compared to individuals with an age of onset of opioid use of 31 years or older (odds ratio 2.94, 95% confidence interval 1.20, 7.19, p = 0.02). A significant association was not found between the risk of having a comorbidity and an age of onset of opioid use between 18 and 25 years or 26 and 30 years, compared to an age of onset of opioid use of 31 years or older. Conclusion: Our study demonstrates that the younger one begins to use opioids, the greater their chance of having a physical or psychiatric co-morbidity. Understanding the risk posed by an earlier onset of opioid use for the later development of comorbid disorders informs clinical practice about important prognostic predictors and aids in the identification of high-risk patients.
AB - Background: Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this association may inform clinical practice about important prognostic factors of patients on MMT, enabling clinicians to identify high-risk patients. Methods: This study includes data collected between June 2011 and August 2016 for the Genetics of Opioid Addiction research collaborative between McMaster University and the Canadian Addiction Treatment Centers. All patients were interviewed by trained health professionals using the Mini-International Neuropsychiatric Interview and case report forms. Physical comorbidities were verified using patients' electronic medical records. A multi-variable logistic regression model was constructed to determine the strength of the association between age of onset of opioid use and the presence of physical or psychiatric comorbidity while adjusting for current age, sex, body mass index, methadone dose and smoking status. Results: Data from 627 MMT patients with a mean age of 38.8 years (SD = 11.07) were analyzed. Individuals with an age of onset of opioid use younger than 18 years were found to be at higher odds for having a physical or psychiatric comorbid disorder compared to individuals with an age of onset of opioid use of 31 years or older (odds ratio 2.94, 95% confidence interval 1.20, 7.19, p = 0.02). A significant association was not found between the risk of having a comorbidity and an age of onset of opioid use between 18 and 25 years or 26 and 30 years, compared to an age of onset of opioid use of 31 years or older. Conclusion: Our study demonstrates that the younger one begins to use opioids, the greater their chance of having a physical or psychiatric co-morbidity. Understanding the risk posed by an earlier onset of opioid use for the later development of comorbid disorders informs clinical practice about important prognostic predictors and aids in the identification of high-risk patients.
KW - Methadone
KW - Opioid substitution treatment
KW - Opioid use disorder
KW - Risk prediction
KW - Substance use
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U2 - 10.1186/s13722-017-0074-0
DO - 10.1186/s13722-017-0074-0
M3 - Article
C2 - 28347350
AN - SCOPUS:85029290530
SN - 1940-0632
VL - 12
JO - Addiction Science and Clinical Practice
JF - Addiction Science and Clinical Practice
IS - 1
M1 - 9
ER -
