The association between ß-glucocerebrosidase mutations and parkinsonism

Matthew Swan, Rachel Saunders-Pullman

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Mutations in the ß-glucocerebrosidase gene (GBA), which encodes the lysosomal enzyme ß-glucocerebrosidase, have traditionally been implicated in Gaucher disease, an autosomal recessive lysosomal storage disorder. Yet the past two decades have yielded an explosion of epidemiological and basic-science evidence linking mutations in GBA with the development of Parkinson disease (PD) as well. Although the specific contribution of mutant GBA to the pathogenesis of parkinsonism remains unknown, evidence suggests that both loss of function and toxic gain of function by abnormal ß-glucocerebrosidase may be important, and implicates a close relationship between ß- glucocerebrosidase and α-synuclein. Furthermore, multiple lines of evidence suggest that although GBA-associated PD closely mimics idiopathic PD (IPD), it may present at a younger age, and is more frequently complicated by cognitive dysfunction. Understanding the clinical association between GBA and PD, and the relationship between ß-glucocerebrosidase and α-synuclein, may enhance understanding of the pathogenesis of IPD, improve prognostication and treatment of GBA carriers with parkinsonism, and furthermore inform therapies for IPD not due to GBA mutations.

Original languageEnglish (US)
Article number368
JournalCurrent neurology and neuroscience reports
Issue number8
StatePublished - Aug 2013
Externally publishedYes


  • Dementia with Lewy bodies
  • GBA
  • Gaucher disease
  • Parkinson disease
  • Parkinsonism
  • ß-Glucocerebrosidase

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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