The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Anders H. Berg, Terry P. Combs, Xueliang Du, Michael Brownlee, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

2263 Scopus citations


Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.

Original languageEnglish (US)
Pages (from-to)947-953
Number of pages7
JournalNature Medicine
Issue number8
StatePublished - 2001

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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