@article{075aeeca860c47c6baa14fbc2defa132,
title = "Temporal coding of reward value in monkey ventral striatal tonically active neurons",
abstract = "The rostromedioventral striatum is critical for behavior dependent on evaluating rewards. We asked what contribution tonically active neurons (TANs), the putative striatal cholinergic interneurons, make in coding reward value in this part of the striatum. Two female monkeys were given the option to accept or reject an offered reward in each trial, the value of which was signaled by a visual cue. Forty-five percent of the TANs use temporally modulated activity to encode information about discounted value. These responses were significantly better represented using principal component analysis than by just counting spikes. The temporal coding is straightforward: the spikes are distributed according to a sinusoidal envelope of activity that changes gain, ranging from positive to negative according to discounted value. Our results show that the information about the relative value of an offered reward is temporally encoded in neural spike trains of TANs. This temporal coding may allow well tuned, coordinated behavior to emerge.",
keywords = "Monkey, Striatum, Tonically active neurons",
author = "Rossella Falcone and Weintraub, {David B.} and Tsuyoshi Setogawa and Wittig, {John H.} and Gang Chen and Richmond, {Barry J.}",
note = "Funding Information: This work was supported (in part) by the Intramural Research Program of the NIMH and includes the relevant Annual Report number in the following format (ZIAMH002619). We thank Mark Eldridge and Janita Turchi for comments on the paper. The opinions expressed in this article are the authors{\textquoteright} own and do not reflect the views of the NIH, the DHHS, or the United States government. Funding Information: Received April 16, 2019; revised July 15, 2019; accepted July 18, 2019. Authorcontributions:D.B.W.andB.J.R.designedresearch;D.B.W.andJ.H.W.performedresearch;R.F.,T.S.,and B.J.R. analyzed data; G.C. contributed unpublished reagents/analytic tools; R.F. and B.J.R. wrote the paper. This work was supported (in part) by the Intramural Research Program of the NIMH and includes the relevant Annual Report number in the following format (ZIAMH002619). We thank Mark Eldridge and Janita Turchi for comments on the paper. The opinions expressed in this article are the authors{\textquoteright} own and do not reflect the views of the NIH, the DHHS, or the United States government. The authors declare no competing financial interests. *R.F. and D.B.W. contributed equally to this work. Correspondence should be addressed to Barry J. Richmond at bjr@ln.nimh.nih.gov. https://doi.org/10.1523/JNEUROSCI.0869-19.2019 Copyright {\textcopyright} 2019 the authors Publisher Copyright: Copyright {\textcopyright} 2019 the authors.",
year = "2019",
month = sep,
day = "18",
doi = "10.1523/JNEUROSCI.0869-19.2019",
language = "English (US)",
volume = "39",
pages = "7539--7550",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "38",
}