Abstract
Lung transplantation is now the established treatment modality for end-stage lung parenchymal and vascular disease. The most common indications in lung transplantation are chronic obstructive pulmonary disease/emphysema, interstitial lung disease, alpha-1 antitrypsin, cystic fibrosis, and pulmonary arterial hypertension; together these represent 85% of the patients receiving transplantation. Many centers utilize venoarterial extracorporeal membrane oxygenation (ECMO), rather than CPB, for lung transplantation. This strategy allows for a lower activated clotting time of 180-250 seconds and may result in less bleeding. Intraoperative management of a frozen chest and the associated pneumonectomy can be challenging. In such situation, a wide thoracotomy is recommended. Since the beginning of the COVID-19 pandemic, millions of patients have sustained different degrees of lung injury. Some patients develop COVID-related acute respiratory distress syndrome, requiring mechanical ventilation and at times support with VV ECMO.
Original language | English (US) |
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Title of host publication | Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease |
Publisher | wiley |
Pages | 1193-1203 |
Number of pages | 11 |
ISBN (Electronic) | 9781119633884 |
ISBN (Print) | 9781119633846 |
DOIs | |
State | Published - Jan 1 2023 |
Externally published | Yes |
Keywords
- activated clotting time
- acute respiratory distress syndrome
- chronic obstructive pulmonary disease
- cystic fibrosis
- extracorporeal membrane oxygenation
- interstitial lung disease
- lung transplantation
- mechanical ventilation
- pulmonary arterial hypertension
ASJC Scopus subject areas
- General Medicine