Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

S. G. Baum; M. Wittner; J. P. Nadler; S. B. Horwitz; J. E. Dennis; P. B. Schiff; H. B. Tanowitz

doi:10.1073/pnas.78.7.4571

Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

S. G. Baum, M. Wittner, J. P. Nadler, S. B. Horwitz, J. E. Dennis, P. B. Schiff, H. B. Tanowitz

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85 Scopus citations

Abstract

Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.

Original language	English (US)
Pages (from-to)	4571-4575
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	78
Issue number	7 I
DOIs	https://doi.org/10.1073/pnas.78.7.4571
State	Published - 1981
Externally published	Yes

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title = "Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi",

abstract = "Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.",

author = "Baum, {S. G.} and M. Wittner and Nadler, {J. P.} and Horwitz, {S. B.} and Dennis, {J. E.} and Schiff, {P. B.} and Tanowitz, {H. B.}",

year = "1981",

doi = "10.1073/pnas.78.7.4571",

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TY - JOUR

T1 - Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

AU - Baum, S. G.

AU - Wittner, M.

AU - Nadler, J. P.

AU - Horwitz, S. B.

AU - Dennis, J. E.

AU - Schiff, P. B.

AU - Tanowitz, H. B.

PY - 1981

Y1 - 1981

N2 - Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.

AB - Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.

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Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

Abstract

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