Abstract
Hematopoiesis is the process during which pluripotent stem cells give rise to lineage committed progenitors that differentiate into mature erythroid, myeloid, and lymphoid cells. This is a finely regulated process that is required for optimal maintenance of peripheral blood counts. Alterations in hematopoiesis can lead to a variety of bone marrow failure syndromes and hematological malignancies. Treatment of these diseases requires a detailed study of pathogenic mechanisms that lead to hematopoietic failure.
Original language | English (US) |
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Title of host publication | Molecular Basis of Hematopoiesis |
Publisher | Springer New York |
Pages | 231-252 |
Number of pages | 22 |
ISBN (Print) | 9780387858159 |
DOIs | |
State | Published - 2009 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology