T-cell anergy

Fernando Macián, Sin Hyeog Im, Francisco J. García-Cózar, Anjana Rao

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations


Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 2004


  • CTLA-4
  • Cytotoxic T lymphocyte antigen 4
  • DC
  • Dendritic cell
  • GM-CSF
  • Granulocyte-macrophage colony-stimulating factor
  • IFN
  • IL
  • ILT
  • Ig-like transcript
  • Interferon
  • Interleukin
  • NFAT
  • Nuclear factor of activated T cells
  • T-cell receptor
  • TCR
  • TGF

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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