System-specific neurodegeneration following glucotoxicity in the C. elegans model

Adi Pinkas, Michael Lawes, Michael Aschner

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
StatePublished - Sep 2018


  • Advanced glycation end products
  • C. elegans
  • Glucose
  • Neurodegeneration

ASJC Scopus subject areas

  • General Neuroscience
  • Toxicology


Dive into the research topics of 'System-specific neurodegeneration following glucotoxicity in the C. elegans model'. Together they form a unique fingerprint.

Cite this