TY - JOUR
T1 - Synthesis of Tri-Substituted Olefin Derivatives from 1-Alkene-1,2-Diboronic Esters via Sequential Suzuki-Suzuki Coupling Reaction and Their Biological Activity
AU - Kerketta, Manoranjan
AU - Mali, Maruti
AU - Sridhar, Gattu
AU - Sharma, Gangavaram V.M.
AU - Vankudoth, Jayaram
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Substituted Olefin-based compounds are attractive targets in the design of novel chemical structures for the discovery of new drugs. In the current study, we have synthesized a series of new tri-substituted olefin derivatives (4a–4p) and their chemical structures were confirmed by spectroscopic techniques. The series of molecules were evaluated for anti-cancer potential against four human cancer cell lines such as MDA-MB-232, HepG2, MCF-7 and HEK293. Among the evaluated compounds, ten compounds 4a, 4c, 4d, 4f, 4g, 4h, 4k, 4l, 4m and 4p displayed more potent anticancer activity. Along with anti-cancer we evaluated antimalarial activity of all compounds toward plasmodial strain PF3D7 via SYBR Green I assay approach and screened their Anti tuberculosis interest toward Mycobacterium tuberculosis.
AB - Substituted Olefin-based compounds are attractive targets in the design of novel chemical structures for the discovery of new drugs. In the current study, we have synthesized a series of new tri-substituted olefin derivatives (4a–4p) and their chemical structures were confirmed by spectroscopic techniques. The series of molecules were evaluated for anti-cancer potential against four human cancer cell lines such as MDA-MB-232, HepG2, MCF-7 and HEK293. Among the evaluated compounds, ten compounds 4a, 4c, 4d, 4f, 4g, 4h, 4k, 4l, 4m and 4p displayed more potent anticancer activity. Along with anti-cancer we evaluated antimalarial activity of all compounds toward plasmodial strain PF3D7 via SYBR Green I assay approach and screened their Anti tuberculosis interest toward Mycobacterium tuberculosis.
KW - Anticancer
KW - antimalarial and anti tuberculosis activity
KW - regioselective Suzuki coupling
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U2 - 10.1080/10406638.2021.1991391
DO - 10.1080/10406638.2021.1991391
M3 - Article
AN - SCOPUS:85117238095
SN - 1040-6638
VL - 42
SP - 6750
EP - 6759
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
IS - 9
ER -