Synaptic plasticity of NMDA receptors: Mechanisms and functional implications

David L. Hunt, Pablo E. Castillo

Research output: Contribution to journalReview articlepeer-review

228 Scopus citations


Beyond their well-established role as triggers for LTP and LTD of fast synaptic transmission mediated by AMPA receptors, an expanding body of evidence indicates that NMDA receptors (NMDARs) themselves are also dynamically regulated and subject to activity-dependent long-term plasticity. NMDARs can significantly contribute to information transfer at synapses particularly during periods of repetitive activity. It is also increasingly recognized that NMDARs participate in dendritic synaptic integration and are critical for generating persistent activity of neural assemblies. Here we review recent advances on the mechanisms and functional consequences of NMDAR plasticity. Given the unique biophysical properties of NMDARs, synaptic plasticity of NMDAR-mediated transmission emerges as a particularly powerful mechanism for the fine tuning of information encoding and storage throughout the brain.

Original languageEnglish (US)
Pages (from-to)496-508
Number of pages13
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Neuroscience(all)


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