Symptomatic atrial arrhythmias and transcatheter closure of atrial septal defects in adult patients

C. K. Silversides, S. C. Siu, P. R. McLaughlin, K. L. Haberer, G. D. Webb, L. Benson, L. Harris

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Objective: To determine whether transcatheter device closure of a secundum atrial septal defect (ASD) will reduce the risk of developing subsequent atrial arrhythmias. Design: The incidence and predictors of symptomatic atrial tachyarrhythmias (AT) were examined in adults undergoing transcatheter closure of ASDs. Setting: Toronto Congenital Cardiac Centre for Adults. Patients: 132 consecutive patients, mean (SD) age 44 (16) years; 74% female. Main outcome measure: Sustained or symptomatic atrial arrhythmias at early follow up (six weeks; n = 115) and intermediate follow up (last clinic visit 17 (11) months post surgery; n = 121). Results: 15% of the patients (20 of 132) had AT before the procedure (14 paroxysmal, six persistent). Patients without a history of arrhythmia had a low incidence of AT during early follow up (6%) and intermediate follow up (1%/year), while all patients with persistent AT before closure remained in atrial fibrillation or flutter. Of patients in sinus rhythm but with a previous history of AT, two thirds remained arrhythmia-free at follow up, with overall incidences of paroxysmal and persistent AT of 17%/year and 11%/year. A history of AT before closure (risk ratio (RR) 35.0, 95% confidence interval (CI) 7.2 to 169.0) and age ≥ 55 years at the time of device insertion (RR 5.6,95% CI 1.2 to 25.0) predicted AT after closure. Conclusions: Device closure of an ASD before the onset of atrial arrhythmias may protect against the subsequent development of arrhythmia, in particular in patients less than 55 years of age.

Original languageEnglish (US)
Pages (from-to)1194-1198
Number of pages5
Issue number10
StatePublished - Oct 2004
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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