Sympathetic nervous system signaling in heart failure and cardiac aging

Gaetano Santulli

doi:10.1007/978-3-319-15961-4_5

Sympathetic nervous system signaling in heart failure and cardiac aging

Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

Heart failure represents the leading cause of death, especially among the elderly. Despite the development of numerous therapeutic strategies, heart failure prevalence is still increasing. Ergo, exploring the molecular mechanisms underlying aging-related heart failure seems to be of particular relevance. Intriguingly, the fields of cardiovascular disease and aging, which have remained largely separate hitherto, seem to have a common point in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disease. This chapter will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiac aging.

Original language	English (US)
Title of host publication	Pathophysiology and Pharmacotherapy of Cardiovascular Disease
Publisher	Springer International Publishing
Pages	83-105
Number of pages	23
ISBN (Electronic)	9783319159614
ISBN (Print)	9783319159607
DOIs	https://doi.org/10.1007/978-3-319-15961-4_5
State	Published - Jan 1 2015
Externally published	Yes

Keywords

Adrenergic receptors
Aging
Arrhythmias
Cardiomyocytes
Endothelium
GRKs
Heart failure
Hypertension
Sympathetic nervous system

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-15961-4_5

Cite this

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title = "Sympathetic nervous system signaling in heart failure and cardiac aging",

abstract = "Heart failure represents the leading cause of death, especially among the elderly. Despite the development of numerous therapeutic strategies, heart failure prevalence is still increasing. Ergo, exploring the molecular mechanisms underlying aging-related heart failure seems to be of particular relevance. Intriguingly, the fields of cardiovascular disease and aging, which have remained largely separate hitherto, seem to have a common point in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disease. This chapter will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiac aging.",

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AB - Heart failure represents the leading cause of death, especially among the elderly. Despite the development of numerous therapeutic strategies, heart failure prevalence is still increasing. Ergo, exploring the molecular mechanisms underlying aging-related heart failure seems to be of particular relevance. Intriguingly, the fields of cardiovascular disease and aging, which have remained largely separate hitherto, seem to have a common point in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disease. This chapter will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiac aging.

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KW - Arrhythmias

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KW - Endothelium

KW - GRKs

KW - Heart failure

KW - Hypertension

KW - Sympathetic nervous system

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ER -

Sympathetic nervous system signaling in heart failure and cardiac aging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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