Sympathetic drive is modulated by central chemoreceptor activation

Chris Pitsikoulis; Matthew N. Bartels; Gregory Gates; Rebecca A. Rebmann; Aimee M. Layton; Ronald E. De Meersman

doi:10.1016/j.resp.2008.08.010

Sympathetic drive is modulated by central chemoreceptor activation

Chris Pitsikoulis, Matthew N. Bartels, Gregory Gates, Rebecca A. Rebmann, Aimee M. Layton, Ronald E. De Meersman

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To determine the effects of central chemoreceptor stimulation upon sympathetic modulation while minimizing baroreceptor influences, we performed a single-blind, counter-balanced, placebo-controlled trial of a modified hypercapnic/hyperoxic rebreathe protocol stimulus to activate the central chemoreflex. Muscle sympathetic nerve activity (MSNA), heart rate, blood pressure, and ventilation were recorded dynamically as subjects transitioned from a hypocapnia to hypercapnia state. The stages of data recording were defined as hyperventilation (HyV), pre-threshold (PreT) and post-threshold (PostT), with threshold being defined as the point of non-linear deviation in ventilation. The changes in MSNA (-4.2 ± 52.4 arbitrary units (AU) vs. 245.0 ± 84.0 AU) and burst count (-0.1 ± 0.7 bursts/segment vs. 2.5 ± 1.7 bursts/segment) were significantly different between control and rebreathe for the HyV to PreT step. There was also a significant difference for PreT to PostT for total MSNA (3.9 ± 65.4 AU vs. 183.7 ± 104.2 AU). In a hypercapnic/hyperoxic state, the central chemoreceptors modulate sympathetic activity below the chemoreflex threshold independently of the baroreceptors, possibly contributing to basal autonomic/sympathetic tone. Central chemoreceptors also appear to play a significant role in sympathetic modulation after the threshold.

Original language	English (US)
Pages (from-to)	373-379
Number of pages	7
Journal	Respiratory Physiology and Neurobiology
Volume	164
Issue number	3
DOIs	https://doi.org/10.1016/j.resp.2008.08.010
State	Published - Dec 31 2008
Externally published	Yes

Keywords

Chemoreceptor
Muscle sympathetic nerve activity
Systolic blood pressure
Ventilation

ASJC Scopus subject areas

General Neuroscience
Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.resp.2008.08.010

Cite this

@article{fdc861f72be44a4f82dec17b00ea4686,

title = "Sympathetic drive is modulated by central chemoreceptor activation",

abstract = "To determine the effects of central chemoreceptor stimulation upon sympathetic modulation while minimizing baroreceptor influences, we performed a single-blind, counter-balanced, placebo-controlled trial of a modified hypercapnic/hyperoxic rebreathe protocol stimulus to activate the central chemoreflex. Muscle sympathetic nerve activity (MSNA), heart rate, blood pressure, and ventilation were recorded dynamically as subjects transitioned from a hypocapnia to hypercapnia state. The stages of data recording were defined as hyperventilation (HyV), pre-threshold (PreT) and post-threshold (PostT), with threshold being defined as the point of non-linear deviation in ventilation. The changes in MSNA (-4.2 ± 52.4 arbitrary units (AU) vs. 245.0 ± 84.0 AU) and burst count (-0.1 ± 0.7 bursts/segment vs. 2.5 ± 1.7 bursts/segment) were significantly different between control and rebreathe for the HyV to PreT step. There was also a significant difference for PreT to PostT for total MSNA (3.9 ± 65.4 AU vs. 183.7 ± 104.2 AU). In a hypercapnic/hyperoxic state, the central chemoreceptors modulate sympathetic activity below the chemoreflex threshold independently of the baroreceptors, possibly contributing to basal autonomic/sympathetic tone. Central chemoreceptors also appear to play a significant role in sympathetic modulation after the threshold.",

keywords = "Chemoreceptor, Muscle sympathetic nerve activity, Systolic blood pressure, Ventilation",

author = "Chris Pitsikoulis and Bartels, {Matthew N.} and Gregory Gates and Rebmann, {Rebecca A.} and Layton, {Aimee M.} and {De Meersman}, {Ronald E.}",

year = "2008",

month = dec,

day = "31",

doi = "10.1016/j.resp.2008.08.010",

language = "English (US)",

volume = "164",

pages = "373--379",

journal = "Respiratory Physiology and Neurobiology",

issn = "1569-9048",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Sympathetic drive is modulated by central chemoreceptor activation

AU - Pitsikoulis, Chris

AU - Bartels, Matthew N.

AU - Gates, Gregory

AU - Rebmann, Rebecca A.

AU - Layton, Aimee M.

AU - De Meersman, Ronald E.

PY - 2008/12/31

Y1 - 2008/12/31

N2 - To determine the effects of central chemoreceptor stimulation upon sympathetic modulation while minimizing baroreceptor influences, we performed a single-blind, counter-balanced, placebo-controlled trial of a modified hypercapnic/hyperoxic rebreathe protocol stimulus to activate the central chemoreflex. Muscle sympathetic nerve activity (MSNA), heart rate, blood pressure, and ventilation were recorded dynamically as subjects transitioned from a hypocapnia to hypercapnia state. The stages of data recording were defined as hyperventilation (HyV), pre-threshold (PreT) and post-threshold (PostT), with threshold being defined as the point of non-linear deviation in ventilation. The changes in MSNA (-4.2 ± 52.4 arbitrary units (AU) vs. 245.0 ± 84.0 AU) and burst count (-0.1 ± 0.7 bursts/segment vs. 2.5 ± 1.7 bursts/segment) were significantly different between control and rebreathe for the HyV to PreT step. There was also a significant difference for PreT to PostT for total MSNA (3.9 ± 65.4 AU vs. 183.7 ± 104.2 AU). In a hypercapnic/hyperoxic state, the central chemoreceptors modulate sympathetic activity below the chemoreflex threshold independently of the baroreceptors, possibly contributing to basal autonomic/sympathetic tone. Central chemoreceptors also appear to play a significant role in sympathetic modulation after the threshold.

AB - To determine the effects of central chemoreceptor stimulation upon sympathetic modulation while minimizing baroreceptor influences, we performed a single-blind, counter-balanced, placebo-controlled trial of a modified hypercapnic/hyperoxic rebreathe protocol stimulus to activate the central chemoreflex. Muscle sympathetic nerve activity (MSNA), heart rate, blood pressure, and ventilation were recorded dynamically as subjects transitioned from a hypocapnia to hypercapnia state. The stages of data recording were defined as hyperventilation (HyV), pre-threshold (PreT) and post-threshold (PostT), with threshold being defined as the point of non-linear deviation in ventilation. The changes in MSNA (-4.2 ± 52.4 arbitrary units (AU) vs. 245.0 ± 84.0 AU) and burst count (-0.1 ± 0.7 bursts/segment vs. 2.5 ± 1.7 bursts/segment) were significantly different between control and rebreathe for the HyV to PreT step. There was also a significant difference for PreT to PostT for total MSNA (3.9 ± 65.4 AU vs. 183.7 ± 104.2 AU). In a hypercapnic/hyperoxic state, the central chemoreceptors modulate sympathetic activity below the chemoreflex threshold independently of the baroreceptors, possibly contributing to basal autonomic/sympathetic tone. Central chemoreceptors also appear to play a significant role in sympathetic modulation after the threshold.

KW - Chemoreceptor

KW - Muscle sympathetic nerve activity

KW - Systolic blood pressure

KW - Ventilation

UR - http://www.scopus.com/inward/record.url?scp=56449094091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56449094091&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2008.08.010

DO - 10.1016/j.resp.2008.08.010

M3 - Article

C2 - 18840550

AN - SCOPUS:56449094091

SN - 1569-9048

VL - 164

SP - 373

EP - 379

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

IS - 3

ER -

Sympathetic drive is modulated by central chemoreceptor activation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this