Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc

George Vlad; Michael B. Stokes; Zhuoru Liu; Chih Chao Chang; Hugo Sondermeijer; Elena R. Vasilescu; Adriana I. Colovai; Pasquale Berloco; Vivette D. D'Agati; Lloyd Ratner; Raffaello Cortesini; Nicole Suciu-Foca

doi:10.1016/j.humimm.2009.06.001

Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc

George Vlad, Michael B. Stokes, Zhuoru Liu, Chih Chao Chang, Hugo Sondermeijer, Elena R. Vasilescu, Adriana I. Colovai, Pasquale Berloco, Vivette D. D'Agati, Lloyd Ratner, Raffaello Cortesini, Nicole Suciu-Foca

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) γ-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8⁺ T suppressor cells and blocks the cellular and humoral arm of the GVH reaction.

Original language	English (US)
Pages (from-to)	663-669
Number of pages	7
Journal	Human Immunology
Volume	70
Issue number	9
DOIs	https://doi.org/10.1016/j.humimm.2009.06.001
State	Published - Sep 2009
Externally published	Yes

Keywords

CD8 T suppressor cells
GVHD
ILT3

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.humimm.2009.06.001

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@article{1191ed4e090c45539fa93e952d2702e0,

title = "Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc",

abstract = "Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) γ-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8+ T suppressor cells and blocks the cellular and humoral arm of the GVH reaction.",

keywords = "CD8 T suppressor cells, GVHD, ILT3",

author = "George Vlad and Stokes, {Michael B.} and Zhuoru Liu and Chang, {Chih Chao} and Hugo Sondermeijer and Vasilescu, {Elena R.} and Colovai, {Adriana I.} and Pasquale Berloco and D'Agati, {Vivette D.} and Lloyd Ratner and Raffaello Cortesini and Nicole Suciu-Foca",

note = "Funding Information: This work was supported by grants from the Juvenile Diabetes Research Foundation (1-2008-550) and the Interuniversitary Organ Transplantation Consortium, Rome, Italy. The authors gratefully acknowledge the gene array analysis performed by Dr. Richard Friedman (Department of Biomedical Informatics, Columbia University Medical Center).",

year = "2009",

month = sep,

doi = "10.1016/j.humimm.2009.06.001",

language = "English (US)",

volume = "70",

pages = "663--669",

journal = "Human Immunology",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc

AU - Vlad, George

AU - Stokes, Michael B.

AU - Liu, Zhuoru

AU - Chang, Chih Chao

AU - Sondermeijer, Hugo

AU - Vasilescu, Elena R.

AU - Colovai, Adriana I.

AU - Berloco, Pasquale

AU - D'Agati, Vivette D.

AU - Ratner, Lloyd

AU - Cortesini, Raffaello

AU - Suciu-Foca, Nicole

N1 - Funding Information: This work was supported by grants from the Juvenile Diabetes Research Foundation (1-2008-550) and the Interuniversitary Organ Transplantation Consortium, Rome, Italy. The authors gratefully acknowledge the gene array analysis performed by Dr. Richard Friedman (Department of Biomedical Informatics, Columbia University Medical Center).

PY - 2009/9

Y1 - 2009/9

N2 - Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) γ-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8+ T suppressor cells and blocks the cellular and humoral arm of the GVH reaction.

AB - Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) γ-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8+ T suppressor cells and blocks the cellular and humoral arm of the GVH reaction.

KW - CD8 T suppressor cells

KW - GVHD

KW - ILT3

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Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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