Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

Ann Tempel; R. Suzanne Zukin; Eliot L. Gardner

doi:10.1016/0024-3205(82)90391-5

Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

Ann Tempel, R. Suzanne Zukin, Eliot L. Gardner

Neuroscience

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [³H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.

Original language	English (US)
Pages (from-to)	1401-1404
Number of pages	4
Journal	Life Sciences
Volume	31
Issue number	12-13
DOIs	https://doi.org/10.1016/0024-3205(82)90391-5
State	Published - Sep 1982

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(82)90391-5

Cite this

@article{e74fffd7ef68442dbdd4e4755095e857,

title = "Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment",

abstract = "Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [3H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.",

author = "Ann Tempel and Zukin, {R. Suzanne} and Gardner, {Eliot L.}",

year = "1982",

month = sep,

doi = "10.1016/0024-3205(82)90391-5",

language = "English (US)",

volume = "31",

pages = "1401--1404",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "12-13",

}

TY - JOUR

T1 - Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

AU - Tempel, Ann

AU - Zukin, R. Suzanne

AU - Gardner, Eliot L.

PY - 1982/9

Y1 - 1982/9

N2 - Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [3H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.

AB - Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [3H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.

UR - http://www.scopus.com/inward/record.url?scp=0020463792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020463792&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(82)90391-5

DO - 10.1016/0024-3205(82)90391-5

M3 - Article

C2 - 6292636

AN - SCOPUS:0020463792

SN - 0024-3205

VL - 31

SP - 1401

EP - 1404

JO - Life Sciences

JF - Life Sciences

IS - 12-13

ER -

Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this