Sulfonamides without trimethoprim in the treatment of Nocardia infections: A case report and literature review

Heather Root; Lindsay Daniels; Ashley Marx; Luther A. Bartelt; Anne M. Lachiewicz; David van Duin

doi:10.1111/tid.13452

Sulfonamides without trimethoprim in the treatment of Nocardia infections: A case report and literature review

Heather Root, Lindsay Daniels, Ashley Marx, Luther A. Bartelt, Anne M. Lachiewicz, David van Duin

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Sulfonamides are recommended as part of first-line therapy for most Nocardia infections, with trimethoprim-sulfamethoxazole (TMP-SMX) considered the drug of choice for susceptible isolates. However, in the case of central nervous system, disseminated disease, and other serious Nocardia infections, TMP-SMX should not be used as monotherapy. The preferred treatment for a patient unable to take TMP-SMX because of allergy or intolerance remains uncertain. Prior to the availability of TMP-SMX in 1973, other sulfonamides were mainstays of treatment. We describe a Nocardia infection successfully treated with sulfadiazine in a lung transplant recipient who could not tolerate TMP-SMX. A review of similar cases reported in the literature provides insight into the successful treatment of Nocardia infections with sulfonamide regimens not containing trimethoprim in transplant recipients and other immunocompromised hosts.

Original language	English (US)
Article number	e13452
Journal	Transplant Infectious Disease
Volume	23
Issue number	1
DOIs	https://doi.org/10.1111/tid.13452
State	Published - Feb 2021
Externally published	Yes

Keywords

Nocardia
immunocompromised
sulfadiazine
sulfisoxazole
sulfonamide
transplant
trimethoprim

ASJC Scopus subject areas

Infectious Diseases
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.13452

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title = "Sulfonamides without trimethoprim in the treatment of Nocardia infections: A case report and literature review",

abstract = "Sulfonamides are recommended as part of first-line therapy for most Nocardia infections, with trimethoprim-sulfamethoxazole (TMP-SMX) considered the drug of choice for susceptible isolates. However, in the case of central nervous system, disseminated disease, and other serious Nocardia infections, TMP-SMX should not be used as monotherapy. The preferred treatment for a patient unable to take TMP-SMX because of allergy or intolerance remains uncertain. Prior to the availability of TMP-SMX in 1973, other sulfonamides were mainstays of treatment. We describe a Nocardia infection successfully treated with sulfadiazine in a lung transplant recipient who could not tolerate TMP-SMX. A review of similar cases reported in the literature provides insight into the successful treatment of Nocardia infections with sulfonamide regimens not containing trimethoprim in transplant recipients and other immunocompromised hosts.",

keywords = "Nocardia, immunocompromised, sulfadiazine, sulfisoxazole, sulfonamide, transplant, trimethoprim",

author = "Heather Root and Lindsay Daniels and Ashley Marx and Bartelt, {Luther A.} and Lachiewicz, {Anne M.} and {van Duin}, David",

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year = "2021",

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doi = "10.1111/tid.13452",

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journal = "Transplant Infectious Disease",

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AU - Daniels, Lindsay

AU - Marx, Ashley

AU - Bartelt, Luther A.

AU - Lachiewicz, Anne M.

AU - van Duin, David

PY - 2021/2

Y1 - 2021/2

N2 - Sulfonamides are recommended as part of first-line therapy for most Nocardia infections, with trimethoprim-sulfamethoxazole (TMP-SMX) considered the drug of choice for susceptible isolates. However, in the case of central nervous system, disseminated disease, and other serious Nocardia infections, TMP-SMX should not be used as monotherapy. The preferred treatment for a patient unable to take TMP-SMX because of allergy or intolerance remains uncertain. Prior to the availability of TMP-SMX in 1973, other sulfonamides were mainstays of treatment. We describe a Nocardia infection successfully treated with sulfadiazine in a lung transplant recipient who could not tolerate TMP-SMX. A review of similar cases reported in the literature provides insight into the successful treatment of Nocardia infections with sulfonamide regimens not containing trimethoprim in transplant recipients and other immunocompromised hosts.

AB - Sulfonamides are recommended as part of first-line therapy for most Nocardia infections, with trimethoprim-sulfamethoxazole (TMP-SMX) considered the drug of choice for susceptible isolates. However, in the case of central nervous system, disseminated disease, and other serious Nocardia infections, TMP-SMX should not be used as monotherapy. The preferred treatment for a patient unable to take TMP-SMX because of allergy or intolerance remains uncertain. Prior to the availability of TMP-SMX in 1973, other sulfonamides were mainstays of treatment. We describe a Nocardia infection successfully treated with sulfadiazine in a lung transplant recipient who could not tolerate TMP-SMX. A review of similar cases reported in the literature provides insight into the successful treatment of Nocardia infections with sulfonamide regimens not containing trimethoprim in transplant recipients and other immunocompromised hosts.

KW - Nocardia

KW - immunocompromised

KW - sulfadiazine

KW - sulfisoxazole

KW - sulfonamide

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KW - trimethoprim

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Sulfonamides without trimethoprim in the treatment of Nocardia infections: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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