Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

Ugochi O. Ogu, Ghada Abusin, Rolla Abu-Arja, Janice Staber

Research output: Contribution to journalArticlepeer-review


Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.
Original languageEnglish (US)
Article number7654278
Number of pages5
JournalCase Reports in Pediatrics
StatePublished - Oct 8 2018

ASJC Scopus subject areas

  • Hematology
  • Pediatrics, Perinatology, and Child Health


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