Substrate specificity: PI(3)Kγ has it both ways

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)Kγ. Phosphorylation of tropomyosin is required for β-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

Original languageEnglish (US)
Pages (from-to)773-774
Number of pages2
JournalNature Cell Biology
Issue number8
StatePublished - Aug 1 2005

ASJC Scopus subject areas

  • Cell Biology


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