Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Brandilyn A. Peters-Samuelson; Adam M. Whalen; Xiaonan (Nan) Xue; Elizabeth F. Topper; Kathleen M. Weber; Phyllis C. Tien; Seble G. Kassaye; Howard Minkoff; Ervin Fox; Margaret A. Fischl; Lauren F. Collins; Michelle Floris-Moore; Howard N. Hodis; Qibin Qi; David B. Hanna; Anjali Sharma; Kathryn Anastos; Robert C. Kaplan

doi:10.1093/infdis/jiad488

Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Brandilyn A. Peters-Samuelson, Adam M. Whalen, Xiaonan (Nan) Xue, Elizabeth F. Topper, Kathleen M. Weber, Phyllis C. Tien, Seble G. Kassaye, Howard Minkoff, Ervin Fox, Margaret A. Fischl, Lauren F. Collins, Michelle Floris-Moore, Howard N. Hodis, Qibin Qi, David B. Hanna, Anjali Sharma, Kathryn Anastos, Robert C. Kaplan

Research output: Contribution to journal › Article › peer-review

Abstract

The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women’s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

Original language	English (US)
Pages (from-to)	780-785
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	229
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiad488
State	Published - Mar 15 2024

Keywords

atherosclerosis
cardiovascular disease
HIV
menopause

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiad488

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Peters-Samuelson, B. A., Whalen, A. M., Xue, X., Topper, E. F., Weber, K. M., Tien, P. C., Kassaye, S. G., Minkoff, H., Fox, E., Fischl, M. A., Collins, L. F., Floris-Moore, M., Hodis, H. N., Qi, Q., Hanna, D. B., Sharma, A., Anastos, K., & Kaplan, R. C. (2024). Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV. Journal of Infectious Diseases, 229(3), 780-785. https://doi.org/10.1093/infdis/jiad488

Peters-Samuelson, BA , Whalen, AM , Xue, X, Topper, EF, Weber, KM, Tien, PC, Kassaye, SG, Minkoff, H, Fox, E, Fischl, MA, Collins, LF, Floris-Moore, M, Hodis, HN, Qi, Q , Hanna, DB , Sharma, A , Anastos, K & Kaplan, RC 2024, 'Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV', Journal of Infectious Diseases, vol. 229, no. 3, pp. 780-785. https://doi.org/10.1093/infdis/jiad488

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title = "Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV",

abstract = "The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women{\textquoteright}s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.",

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author = "Peters-Samuelson, {Brandilyn A.} and Whalen, {Adam M.} and Xue, {Xiaonan (Nan)} and Topper, {Elizabeth F.} and Weber, {Kathleen M.} and Tien, {Phyllis C.} and Kassaye, {Seble G.} and Howard Minkoff and Ervin Fox and Fischl, {Margaret A.} and Collins, {Lauren F.} and Michelle Floris-Moore and Hodis, {Howard N.} and Qibin Qi and Hanna, {David B.} and Anjali Sharma and Kathryn Anastos and Kaplan, {Robert C.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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doi = "10.1093/infdis/jiad488",

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AU - Peters-Samuelson, Brandilyn A.

AU - Whalen, Adam M.

AU - Xue, Xiaonan (Nan)

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AU - Weber, Kathleen M.

AU - Tien, Phyllis C.

AU - Kassaye, Seble G.

AU - Minkoff, Howard

AU - Fox, Ervin

AU - Fischl, Margaret A.

AU - Collins, Lauren F.

AU - Floris-Moore, Michelle

AU - Hodis, Howard N.

AU - Qi, Qibin

AU - Hanna, David B.

AU - Sharma, Anjali

AU - Anastos, Kathryn

AU - Kaplan, Robert C.

PY - 2024/3/15

Y1 - 2024/3/15

N2 - The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women’s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

AB - The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women’s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

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Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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