TY - JOUR
T1 - Studies with RP 56976 (taxotere)
T2 - A semisynthetic analogue of taxol
AU - Ringel, Israel
AU - Horwitz, Susan Band
PY - 1991/2/20
Y1 - 1991/2/20
N2 - RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, Promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells. [J Natl Cancer Inst 83:288-291, 1991].
AB - RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, Promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells. [J Natl Cancer Inst 83:288-291, 1991].
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U2 - 10.1093/jnci/83.4.288
DO - 10.1093/jnci/83.4.288
M3 - Article
C2 - 1671606
AN - SCOPUS:0026428123
SN - 0027-8874
VL - 83
SP - 288
EP - 291
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 4
ER -
