Structures and mechanisms of the mycothiol biosynthetic enzymes

Fan Fan, Matthew W. Vetting, Patrick A. Frantom, John S. Blanchard

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


In the past decade, the genes encoding all four enzymes responsible for the biosynthesis of mycothiol in Mycobacterium tuberculosis have been identified. Orthologs of each of these have been stably expressed and structurally characterized. The chemical mechanisms of all the four have also been studied. Because of the unique phylogenetic distribution of mycothiol, and the enzymes responsible for its biosynthesis, these enzymes represent interesting potential targets for antimycobacterial agents.

Original languageEnglish (US)
Pages (from-to)451-459
Number of pages9
JournalCurrent Opinion in Chemical Biology
Issue number4
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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