Structure and mechanism of ATP-dependent proteases

Marion Schmidt, Andrei N. Lupas, Daniel Finley

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.

Original languageEnglish (US)
Pages (from-to)584-591
Number of pages8
JournalCurrent Opinion in Chemical Biology
Issue number5
StatePublished - Oct 1 1999

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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