Structural basis for the coevolution of a viral RNA-protein complex

Jeffrey A. Chao; Yury Patskovsky; Steven C. Almo; Robert H. Singer

doi:10.1038/nsmb1327

Structural basis for the coevolution of a viral RNA-protein complex

Jeffrey A. Chao, Yury Patskovsky, Steven C. Almo, Robert H. Singer

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved β-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

Original language	English (US)
Pages (from-to)	103-105
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/nsmb1327
State	Published - Jan 2008

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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abstract = "The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved β-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.",

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Structural basis for the coevolution of a viral RNA-protein complex

Abstract

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