Structural basis for the coevolution of a viral RNA-protein complex

Jeffrey A. Chao, Yury Patskovsky, Steven C. Almo, Robert H. Singer

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved β-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalNature Structural and Molecular Biology
Issue number1
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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