Striatal "function-metabolism" mismatch on F-18 FDG/F-18 FDOPA PET/CT

Madhavi Tripathi, Rajnish Sharma, Abhinav Jaimini, Gunjan Garg, Aditi Khurana, Maria D'Souza, Raunak Varshney, Anil Mishra, Anupam Mondal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Decrease in gray matter metabolism following cranial irradiation has been documented, but the functional relevance of this finding has not been documented. This case of "function-metabolism" mismatch in the striatum following radiation for a grade III frontoparietal glioma demonstrates that the down-regulation of glucose metabolism as demonstrated by F-18 fluorodeoxyglucose positron emission tomography/computed tomography is associated with preservation of presynaptic dopaminergic function by the striatal neurons which was demonstrated on a correlative l-3,4-dihydroxy-6-F- flurophenylalanine (F-18 FDOPA) study. The reversibility of this down-regulation is demonstrated in a follow-up scan further proving that there is no neurodegeneration involved.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalClinical nuclear medicine
Issue number10
StatePublished - Oct 2009
Externally publishedYes


  • F-18 FDG
  • F-18 FDOPA
  • Mismatch
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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