Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients With Ischemia and Nonobstructive Coronary Arteries (INOCA)

Pasquale Mone, Angela Lombardi, Luigi Salemme, Angelo Cioppa, Grigore Popusoi, Fahimeh Varzideh, Antonella Pansini, Stanislovas S. Jankauskas, Imma Forzano, Roberta Avvisato, Xujun Wang, Tullio Tesorio, Gaetano Santulli

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

OBJECTIVE Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being re-hospitalized for chest pain in patients with INOCA remain mostly unknown. RESEARCH DESIGN AND METHODS We evaluated INOCA patients referred to the “Casa di Cura Montevergine” in Mercogliano (Avellino), Italy, from January 2016 to January 2021 for percutaneous coronary intervention (PCI). In these subjects, we assessed the impact of the stress hyperglycemia ratio (SHR), defined as the ratio of mmol/L blood glucose and % HbA1c, on the risk of rehospitalization for chest pain. RESULTS A total of 2,874 patients with INOCA successfully completed the study. At the 1-year follow-up, the risk of rehospitalization for chest pain was significantly higher (P < 0.001) in INOCA patients with SHR >1 compared to patients with SHR £1. These findings were confirmed by multivariable analyses (adjusting for poten-tial confounders, including age, BMI, blood pressure, heart rate, chronic kidney disease, and cholesterol), propensity score matching, and inverse probability of treatment weighting. CONCLUSIONS Our data indicate, to our knowledge for the first time, that SHR on hospital admission significantly and independently increases the risk of rehospitalization for chest pain in INOCA patients.

Original languageEnglish (US)
Pages (from-to)450-454
Number of pages5
JournalDiabetes care
Volume46
Issue number2
DOIs
StatePublished - Feb 2023

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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