@article{8ffcce154864409895f5d7a3603f940d,
title = "Sphingomyelin Lipidosis in a Cat",
abstract = "A 7-month-old Balinese cat with progressive neurological dysfunction had histopathological lesions of brain, liver, kidney, spleen, and lung consistent with a lysosomal storage disease. Ultrastructural examination revealed lysosomal hypertrophy with membranous inclusions. Hepatic sphingomyelin and cholesterol were elevated 10 times normal, and total phospholipids were increased 3.6 fold. Sphingomyelinase activity measured with 14C labeled sphingomyelin at pH 5.0 was virtually absent in brain and liver. Other lysosomal hydrolase activities were normal or elevated. Clinical, morphological, and biochemical findings suggest that this cat had sphingomyelin lipidosis similar to human Niemann-Pick disease type A, and that feline sphingomyelin lipidosis provides another model of human lysosomal storage disease.",
author = "Baker, {H. J.} and Wood, {P. A.} and Wenger, {D. A.} and Walkley, {S. U.} and K. Inui and T. Kudoh and Rattazzi, {M. C.} and Riddle, {B. L.}",
note = "Funding Information: Baker H. J. Wood P. A. Wenger D. A. Walkley S. U. Inui K. Kudoh T. Rattazzi M. C. Riddle B. L. Department of Comparative Medicine, Bowman Gray School of Medicine, Winston-Salem, NC Department of Pediatrics, University of Colorado Health Science Center, Denver, CO Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY Division of Human Genetics, Children's Hospital of Buffalo, Buffalo, NY Abrams Veterinary Hospital, Dallas, TX Request reprints from Dr. Henry J. Baker, Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103, USA. 9 1987 24 5 386 391 {\textcopyright} 1987 American College of Veterinary Pathologists 1987 American College of Veterinary Pathologists A 7-month-old Balinese cat with progressive neurological dysfunction had histopathological lesions of brain, liver, kidney, spleen, and lung consistent with a lysosomal storage disease. Ultrastructural examination revealed lysosomal hypertrophy with membranous inclusions. Hepatic sphingomyelin and cholesterol were elevated 10 times normal, and total phospholipids were increased 3.6 fold. Sphingomyelinase activity measured with 14 C labeled sphingomyelin at pH 5.0 was virtually absent in brain and liver. Other lysosomal hydrolase activities were normal or elevated. Clinical, morphological, and biochemical findings suggest that this cat had sphingomyelin lipidosis similar to human Niemann-Pick disease type A, and that feline sphingomyelin lipidosis provides another model of human lysosomal storage disease. We thank Ms. S. Wurzelmann for electron microscopy, Dr. Trenton Schoeb for discussions of histologic descriptions, and Dr. Kinuko Suzuki for helpful comments. This study was supported by NIH grants RR00463, RR07003, NS10967, NS07512, and NS13677. ",
year = "1987",
month = sep,
doi = "10.1177/030098588702400504",
language = "English (US)",
volume = "24",
pages = "386--391",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "5",
}
