Specific expression of insulin-like growth factor-II in rhabdomyosarcoma tumor cells

C. P. Minniti, M. Tsokos, W. A. Newton, L. J. Helman

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Insulin-like growth factor II (IGF-II) acts as autocrine growth and motility factor in human rhabdomyosarcoma cell lines, and Northern blot analysis of tumor biopsy specimens from both alveolar and embryonal rhabdomyosarcoma demonstrates high levels of IGF-II mRNA expression. To determine the frequency and site of expression of IGF-II in these tumors, the authors performed in situ hybridization. All tumor specimens examined expressed the gene for IGF-II, and this expression was localized to the tumor cells themselves and not to the surrounding stroma. These data suggest that the IGF-II autocrine loop may be operating not only in vitro but also in vivo.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - 1994
Externally publishedYes


  • In situ
  • Insulin-like growth factors
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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