Some effects of intracerebral lead implantation in the rat

Asao Hirano; Joseph A. Kochen

doi:10.1007/BF00686162

Some effects of intracerebral lead implantation in the rat

Asao Hirano, Joseph A. Kochen

Pathology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.

Original language	English (US)
Pages (from-to)	307-315
Number of pages	9
Journal	Acta neuropathologica
Volume	33
Issue number	4
DOIs	https://doi.org/10.1007/BF00686162
State	Published - Dec 1975

Keywords

Brain edema
Endothelial fenestrations
Lead
Pinocytotic vesicles

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00686162

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abstract = "Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.",

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AU - Kochen, Joseph A.

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AB - Pellets of lead acetate were implanted into the forebrains of adult rats which were sacrificed at intervals between 4 days and 4 weeks thereafter. Parenchymal necrosis and a number of reactive changes including edema and macrophage invasion were observed. Lead deposits were found in the extracellular spaces and within macrophages but only to a slight extent within glial or meningeal cells. Vascular changes were quite remarkable and included proliferation and the appearance of fenestrated blood vessels as well as some with tubular bodies and striking increases in the number of pinocytotic vesicles.

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KW - Endothelial fenestrations

KW - Lead

KW - Pinocytotic vesicles

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Some effects of intracerebral lead implantation in the rat

Abstract

Keywords

ASJC Scopus subject areas

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