Somatic variants in mouse myeloma and hybridoma cell lines

D. E. Yelton, W. D. Cook, M. D. Scharff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The preliminary results presented indicate that structural and synthesis variants similar to those that appear in the parent myeloma culture can also be generated from apparently stable hybridomas. Taken together with the anecdotal experience and experiments of others, these findings indicate that it will be necessary to maintain careful quality control on monoclonal antibodies. It may even be advisable to routinely return to the freezer every few months to maintain the original cell line.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalTransplantation proceedings
Issue number3
StatePublished - 1980

ASJC Scopus subject areas

  • Surgery
  • Transplantation


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