TY - JOUR
T1 - Somatic mutation burden in relation to aging and functional life span
T2 - implications for cellular reprogramming and rejuvenation
AU - Maslov, Alexander Y.
AU - Vijg, Jan
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/12
Y1 - 2023/12
N2 - The accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as a function of age under various conditions. Here, we will briefly recapitulate progress in somatic mutation analysis and discuss the possible relationship between somatic mutation burden with functional life span, with a focus on differences between germ cells, stem cells, and differentiated cells.
AB - The accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as a function of age under various conditions. Here, we will briefly recapitulate progress in somatic mutation analysis and discuss the possible relationship between somatic mutation burden with functional life span, with a focus on differences between germ cells, stem cells, and differentiated cells.
UR - http://www.scopus.com/inward/record.url?scp=85175577467&partnerID=8YFLogxK
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U2 - 10.1016/j.gde.2023.102132
DO - 10.1016/j.gde.2023.102132
M3 - Review article
C2 - 37931583
AN - SCOPUS:85175577467
SN - 0959-437X
VL - 83
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
M1 - 102132
ER -