Somatic cell hybrids between Friend erythroleukemia cells and mouse hepatoma cells

Jean François Conscience, Frank H. Ruddle, Arthur Skoultchi, Gretchen J. Darlington

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Somatic cell hybrids between hepatoma and Friend erythroleukemia parental cells were studied for the expression of liver-specific and erythroid properties. Several independent clones were isolated using HAT selection and were shown to be true hybrids by isozyme and chromosome analysis. All displayed a complete extinction of hemoglobin and globin mRNA production, but a retention of albumin and transferrin secretion. The data suggest that erythroid differentiation is being actively inhibited by the hepatoma genome. Possible mechanisms that might explain these results are discussed in the light of current hypotheses regarding the mechanism of cell differentiation.

Original languageEnglish (US)
Pages (from-to)157-172
Number of pages16
JournalSomatic Cell Genetics
Issue number2
StatePublished - Mar 1977

ASJC Scopus subject areas

  • Genetics


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