Sodium polystyrene sulfonate (SPS): Sorbitol-induced colonic necrosis

Mohamad Erfani, Yougandhar Akula, Touraj Zolfaghari, Hilary I. Hertan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Sodium polystyrene sulfonate (SPS) is a cation exchange resin which primarily acts in the colon. It is usually administered with an osmotic laxative (e.g. sorbitol), orally or as a retention enema, to treat hyperkalemia. SPS-sorbitol use has been implicated in damage to different parts of the gastrointestinal (GI) tract. Adverse GI reactions include anorexia, nausea, vomiting, constipation, fecal impaction, intestinal obstruction and intestinal necrosis (rare). We present an uncommon case of ulceration with necrosis of the ascending colon following multiple oral SPS-sorbitol administrations.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalPractical Gastroenterology
Issue number11
StatePublished - Nov 1 2010

ASJC Scopus subject areas

  • Gastroenterology


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