TY - JOUR
T1 - Sociodemographic variation in the oral microbiome
AU - Renson, Audrey
AU - Jones, Heidi E.
AU - Beghini, Francesco
AU - Segata, Nicola
AU - Zolnik, Christine P.
AU - Usyk, Mykhaylo
AU - Moody, Thomas U.
AU - Thorpe, Lorna
AU - Burk, Robert
AU - Waldron, Levi
AU - Dowd, Jennifer B.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/7
Y1 - 2019/7
N2 - Purpose: Variations in the oral microbiome are potentially implicated in social inequalities in oral disease, cancers, and metabolic disease. We describe sociodemographic variation of oral microbiomes in a diverse sample. Methods: We performed 16S rRNA sequencing on mouthwash specimens in a subsample (n = 282) of the 2013–2014 population-based New York City Health and Nutrition Examination Study. We examined differential abundance of 216 operational taxonomic units, and alpha and beta diversity by age, sex, income, education, nativity, and race/ethnicity. For comparison, we examined differential abundance by diet, smoking status, and oral health behaviors. Results: Sixty-nine operational taxonomic units were differentially abundant by any sociodemographic variable (false discovery rate < 0.01), including 27 by race/ethnicity, 21 by family income, 19 by education, 3 by sex. We found 49 differentially abundant by smoking status, 23 by diet, 12 by oral health behaviors. Genera differing for multiple sociodemographic characteristics included Lactobacillus, Prevotella, Porphyromonas, Fusobacterium. Conclusions: We identified oral microbiome variation consistent with health inequalities, more taxa differing by race/ethnicity than diet, and more by SES variables than oral health behaviors. Investigation is warranted into possible mediating effects of the oral microbiome in social disparities in oral and metabolic diseases and cancers.
AB - Purpose: Variations in the oral microbiome are potentially implicated in social inequalities in oral disease, cancers, and metabolic disease. We describe sociodemographic variation of oral microbiomes in a diverse sample. Methods: We performed 16S rRNA sequencing on mouthwash specimens in a subsample (n = 282) of the 2013–2014 population-based New York City Health and Nutrition Examination Study. We examined differential abundance of 216 operational taxonomic units, and alpha and beta diversity by age, sex, income, education, nativity, and race/ethnicity. For comparison, we examined differential abundance by diet, smoking status, and oral health behaviors. Results: Sixty-nine operational taxonomic units were differentially abundant by any sociodemographic variable (false discovery rate < 0.01), including 27 by race/ethnicity, 21 by family income, 19 by education, 3 by sex. We found 49 differentially abundant by smoking status, 23 by diet, 12 by oral health behaviors. Genera differing for multiple sociodemographic characteristics included Lactobacillus, Prevotella, Porphyromonas, Fusobacterium. Conclusions: We identified oral microbiome variation consistent with health inequalities, more taxa differing by race/ethnicity than diet, and more by SES variables than oral health behaviors. Investigation is warranted into possible mediating effects of the oral microbiome in social disparities in oral and metabolic diseases and cancers.
KW - Demographics
KW - Health disparities
KW - Oral microbiome
KW - Social epidemiology
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U2 - 10.1016/j.annepidem.2019.03.006
DO - 10.1016/j.annepidem.2019.03.006
M3 - Article
C2 - 31151886
AN - SCOPUS:85066150567
SN - 1047-2797
VL - 35
SP - 73-80.e2
JO - Annals of Epidemiology
JF - Annals of Epidemiology
ER -