Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Qiaozhi Wei; Fumio Nakahara; Noboru Asada; Dachuan Zhang; Xin Gao; Chunliang Xu; Alan Alfieri; N. Patrik Brodin; Samuel E. Zimmerman; Jessica C. Mar; Chandan Guha; Wenjun Guo; Paul S. Frenette

doi:10.1016/j.devcel.2020.04.012

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Qiaozhi Wei, Fumio Nakahara, Noboru Asada, Dachuan Zhang, Xin Gao, Chunliang Xu, Alan Alfieri, N. Patrik Brodin, Samuel E. Zimmerman, Jessica C. Mar, Chandan Guha, Wenjun Guo, Paul S. Frenette

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.

Original language	English (US)
Pages (from-to)	503-513.e5
Journal	Developmental cell
Volume	53
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2020.04.012
State	Published - Jun 8 2020

Keywords

Snai2/Slug
bone marrow
hematopoietic stem cell niche
mesenchymal stem and progenitor cells
osteopontin/Spp1
self-renewal
stromal cells
transcriptional regulation

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2020.04.012

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@article{e3ad7b1eb6984ca1a9a4b5c9df108107,

title = "Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression",

abstract = "Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.",

keywords = "Snai2/Slug, bone marrow, hematopoietic stem cell niche, mesenchymal stem and progenitor cells, osteopontin/Spp1, self-renewal, stromal cells, transcriptional regulation",

author = "Qiaozhi Wei and Fumio Nakahara and Noboru Asada and Dachuan Zhang and Xin Gao and Chunliang Xu and Alan Alfieri and Brodin, {N. Patrik} and Zimmerman, {Samuel E.} and Mar, {Jessica C.} and Chandan Guha and Wenjun Guo and Frenette, {Paul S.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

day = "8",

doi = "10.1016/j.devcel.2020.04.012",

language = "English (US)",

volume = "53",

pages = "503--513.e5",

journal = "Developmental cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

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TY - JOUR

T1 - Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

AU - Wei, Qiaozhi

AU - Nakahara, Fumio

AU - Asada, Noboru

AU - Zhang, Dachuan

AU - Gao, Xin

AU - Xu, Chunliang

AU - Alfieri, Alan

AU - Brodin, N. Patrik

AU - Zimmerman, Samuel E.

AU - Mar, Jessica C.

AU - Guha, Chandan

AU - Guo, Wenjun

AU - Frenette, Paul S.

PY - 2020/6/8

Y1 - 2020/6/8

N2 - Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.

AB - Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.

KW - Snai2/Slug

KW - bone marrow

KW - hematopoietic stem cell niche

KW - mesenchymal stem and progenitor cells

KW - osteopontin/Spp1

KW - self-renewal

KW - stromal cells

KW - transcriptional regulation

UR - http://www.scopus.com/inward/record.url?scp=85085324450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085324450&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2020.04.012

DO - 10.1016/j.devcel.2020.04.012

M3 - Article

C2 - 32413329

AN - SCOPUS:85085324450

SN - 1534-5807

VL - 53

SP - 503-513.e5

JO - Developmental cell

JF - Developmental cell

IS - 5

ER -

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Abstract

Keywords

ASJC Scopus subject areas

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