Smoking is associated with altered serum and hair essential metal and metalloid levels in women

Anatoly V. Skalny, Eugeny P. Serebryansky, Tatiana V. Korobeinikova, Aristidis Tsatsakis, Constantine Vardavas, Monica M.B. Paoliello, Tatiana I. Sotnikova, Michael Aschner, Alexey A. Tinkov

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The objective of the study was to evaluate the association between smoking and essential metal (Co, Cr, Cu, Fe, Mn, V, Zn) and metalloid (Se) levels in hair and serum of adult women using inductively coupled plasma-mass spectrometry (ICP-MS). In this cross-sectional study, a total of 344 women 20–70 years old including 199 smokers and 145 non-smoking women were enrolled. Serum Cu, Fe, and Zn levels in smoking women were found to be 6%, 8%, and 3% lower of levels in non-smokers, respectively. In contrast, circulating Mn, V, and especially Cr concentrations in smoking women exceeded the respective values in non-smoking women by 5%, 14%, and 54%. Hair Fe and Se levels in smoking women were 17% and 23% lower as compared to non-smoking controls, respectively. In multiple regression models, smoking severity was inversely associated with serum and hair Se concentrations, whereas the relationship to serum and hair Cr was positive. In addition, serum Zn and hair Fe levels were found to be inversely associated with the number of cigarettes per day. These findings hypothesize that health hazards of smoking may be at least in part be mediated by alteration in essential metal and metalloid metabolism.

Original languageEnglish (US)
Article number113249
JournalFood and Chemical Toxicology
StatePublished - Sep 2022


  • Chromium
  • Cigarettes
  • Selenium
  • Tobacco
  • Zinc

ASJC Scopus subject areas

  • Food Science
  • Toxicology


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