TY - JOUR
T1 - Small molecule tyrosine kinase inhibitors and pancreatic cancer—Trials and troubles
AU - Lakkakula, Bhaskar Venkata Kameswara Subrahmanya
AU - Farran, Batoul
AU - Lakkakula, Saikrishna
AU - Peela, Sujatha
AU - Yarla, Nagendra Sastry
AU - Bramhachari, Pallaval Veera
AU - Kamal, Mohammad Amjad
AU - Saddala, Madhu Sudhana
AU - Nagaraju, Ganji Purnachandra
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/6
Y1 - 2019/6
N2 - Pancreatic cancer (PC) is an aggressive carcinoma and the fourth cause of cancer deaths in Western countries. Although surgery is the most effective therapeutic option for PC, the management of unresectable, locally advanced disease is highly challenging. Our improved understanding of pancreatic tumor biology and associated pathways has led to the development of various treatment modalities that can control the metastatic spread of PC. This review intends to present trials of small molecule tyrosine kinase inhibitors (TKIs) in PC management and the troubles encountered due to inevitable acquired resistance to TKIs.
AB - Pancreatic cancer (PC) is an aggressive carcinoma and the fourth cause of cancer deaths in Western countries. Although surgery is the most effective therapeutic option for PC, the management of unresectable, locally advanced disease is highly challenging. Our improved understanding of pancreatic tumor biology and associated pathways has led to the development of various treatment modalities that can control the metastatic spread of PC. This review intends to present trials of small molecule tyrosine kinase inhibitors (TKIs) in PC management and the troubles encountered due to inevitable acquired resistance to TKIs.
KW - Clinical trials
KW - Pancreatic carcinoma
KW - Resistance
KW - Targeted therapies
KW - Tyrosine kinase inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85054426727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054426727&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2018.09.011
DO - 10.1016/j.semcancer.2018.09.011
M3 - Review article
C2 - 30314681
AN - SCOPUS:85054426727
SN - 1044-579X
VL - 56
SP - 149
EP - 167
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -