Abstract
Introduction: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Methods: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive impairment screener (Six-item Screener [SIS]). Results: Mean age was 63 ± 8 years, with 55% of the population being female with 7.0% Central American, 24.5% Cuban, 9.3% Dominican, 35.9% Mexican, 14.4% Puerto Rican, and 5.1% South American background. Long sleep (>9 hours), but not short sleep (<6 hours), was associated with decline (standard deviation units) in episodic learning and memory (βSEVLT-Sum = −0.22 [se = 0.06]; P <.001; βSEVLT-Recall = −0.13 [se = 0.06]; P <.05), WF (Pwf = −0.20 [se 5 0.06]; P <.01), and SIS (βSIS = −0.16 [se = 0.06]; P <.01), but not processing speed, after adjusting for covariates. SDB, sleepiness, and insomnia were not associated with neurocognitive decline. Conclusion: Long sleep duration predicted seven-year cognitive decline.
Original language | English (US) |
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Pages (from-to) | 305-315 |
Number of pages | 11 |
Journal | Alzheimer's and Dementia |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2020 |
Keywords
- Cohort studies
- Hispanic/Latino
- Neurocognitive decline
- Risk factors in epidemiology
- Sleep
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Health Policy
- Developmental Neuroscience
- Epidemiology