Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos

Alberto R. Ramos, Wassim Tarraf, Benson Wu, Susan Redline, Jianwen Cai, Martha L. Daviglus, Linda Gallo, Yasmin Mossavar-Rahmani, Krista M. Perreira, Phyllis Zee, Donglin Zeng, Hector M. Gonzalez

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Introduction: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Methods: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive impairment screener (Six-item Screener [SIS]). Results: Mean age was 63 ± 8 years, with 55% of the population being female with 7.0% Central American, 24.5% Cuban, 9.3% Dominican, 35.9% Mexican, 14.4% Puerto Rican, and 5.1% South American background. Long sleep (>9 hours), but not short sleep (<6 hours), was associated with decline (standard deviation units) in episodic learning and memory (βSEVLT-Sum = −0.22 [se = 0.06]; P <.001; βSEVLT-Recall = −0.13 [se = 0.06]; P <.05), WF (Pwf = −0.20 [se 5 0.06]; P <.01), and SIS (βSIS = −0.16 [se = 0.06]; P <.01), but not processing speed, after adjusting for covariates. SDB, sleepiness, and insomnia were not associated with neurocognitive decline. Conclusion: Long sleep duration predicted seven-year cognitive decline.

Original languageEnglish (US)
Pages (from-to)305-315
Number of pages11
JournalAlzheimer's and Dementia
Issue number2
StatePublished - Feb 1 2020


  • Cohort studies
  • Hispanic/Latino
  • Neurocognitive decline
  • Risk factors in epidemiology
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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