TY - JOUR
T1 - Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos
AU - Ramos, Alberto R.
AU - Tarraf, Wassim
AU - Wu, Benson
AU - Redline, Susan
AU - Cai, Jianwen
AU - Daviglus, Martha L.
AU - Gallo, Linda
AU - Mossavar-Rahmani, Yasmin
AU - Perreira, Krista M.
AU - Zee, Phyllis
AU - Zeng, Donglin
AU - Gonzalez, Hector M.
N1 - Funding Information:
The authors thank the staff and participants of HCHS/SOL and Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) for their important contributions. Investigators website: http://www.cscc.unc.edu/hchs/. Funding: This work is support by the National Institute on Aging (R01AG048642, RF1AG054548, R01AG061022, and R21AG056952). H.M.G. also receives additional sup-port from P30AG005131 and P30AG059299. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01- HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following institutes/cen- ters/offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution- Office of Dietary Supplements. Role of Funding Source: This work was supported by the National Institute on Aging and National Heart, Lung, and Blood Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Funding Information:
Role of Funding Source: This work was supported by the National Institute on Aging and National Heart, Lung, and Blood Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Funding Information:
Funding: This work is support by the National Institute on Aging (R01AG048642, RF1AG054548, R01AG061022, and R21AG056952). H.M.G. also receives additional sup‐port from P30AG005131 and P30AG059299. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01‐ HC65233), University of Miami (N01‐HC65234), Albert Einstein College of Medicine (N01‐HC65235), Northwestern University (N01‐HC65236), and San Diego State University (N01‐HC65237). The following institutes/cen‐ ters/offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution‐ Office of Dietary Supplements.
Publisher Copyright:
© 2019 the Alzheimer's Association
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Introduction: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Methods: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive impairment screener (Six-item Screener [SIS]). Results: Mean age was 63 ± 8 years, with 55% of the population being female with 7.0% Central American, 24.5% Cuban, 9.3% Dominican, 35.9% Mexican, 14.4% Puerto Rican, and 5.1% South American background. Long sleep (>9 hours), but not short sleep (<6 hours), was associated with decline (standard deviation units) in episodic learning and memory (βSEVLT-Sum = −0.22 [se = 0.06]; P <.001; βSEVLT-Recall = −0.13 [se = 0.06]; P <.05), WF (Pwf = −0.20 [se 5 0.06]; P <.01), and SIS (βSIS = −0.16 [se = 0.06]; P <.01), but not processing speed, after adjusting for covariates. SDB, sleepiness, and insomnia were not associated with neurocognitive decline. Conclusion: Long sleep duration predicted seven-year cognitive decline.
AB - Introduction: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Methods: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive impairment screener (Six-item Screener [SIS]). Results: Mean age was 63 ± 8 years, with 55% of the population being female with 7.0% Central American, 24.5% Cuban, 9.3% Dominican, 35.9% Mexican, 14.4% Puerto Rican, and 5.1% South American background. Long sleep (>9 hours), but not short sleep (<6 hours), was associated with decline (standard deviation units) in episodic learning and memory (βSEVLT-Sum = −0.22 [se = 0.06]; P <.001; βSEVLT-Recall = −0.13 [se = 0.06]; P <.05), WF (Pwf = −0.20 [se 5 0.06]; P <.01), and SIS (βSIS = −0.16 [se = 0.06]; P <.01), but not processing speed, after adjusting for covariates. SDB, sleepiness, and insomnia were not associated with neurocognitive decline. Conclusion: Long sleep duration predicted seven-year cognitive decline.
KW - Cohort studies
KW - Hispanic/Latino
KW - Neurocognitive decline
KW - Risk factors in epidemiology
KW - Sleep
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U2 - 10.1016/j.jalz.2019.08.191
DO - 10.1016/j.jalz.2019.08.191
M3 - Article
C2 - 31606367
AN - SCOPUS:85078663992
SN - 1552-5260
VL - 16
SP - 305
EP - 315
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -
