Skin closure with dye-enhanced laser welding and fibrinogen

Todd M. Wider, Steven K. Libutti, Daniel P. Greenwald, Mehmet C. Oz, Jeffrey S. Yager, Michael R. Treat, Norman E. Hugo

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Initial studies of laser welding for skin closure in mouse models demonstrated that while bursting strength was not compromised, the levels of collagen-specific messenger ribonucleic acid were significantly lower when compared to the control group of simple suture closure. A superior cosmetic result of the laser welded incisions was also claimed. Recently, the topical application of wavelength specific dyes has been used to enhance laser closure for vascular anastomoses. Laser welding offers many possible advantages over suture closure including shorter operative time, decreased foreign body reaction, and possibly decreased scar formation. We compared the in vivo closure of cutaneous incisions welded with argon laser/fluorescein isothiocyanate dye (FITC)/fibrinogen, and diode laser/indocyanine green dye (ICG)/fibrinogen, to closure by simple suture.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 1991
EventProceedings of Lasers in Dermatology and Tissue Weldings - Los Angeles, CA, USA
Duration: Jan 21 1991Jan 22 1991

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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