Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors

Cherk S. Tam; Johan N.M. Heersche; Arthur Santora; Allen M. Spiegel

doi:10.1016/0026-0495(84)90161-6

Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors

Cherk S. Tam, Johan N.M. Heersche, Arthur Santora, Allen M. Spiegel

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of Rice H-500 Leydig cell tumor tissue on bone in rats was assessed by morphometric analysis and tetracycline labeling of the lower femoral metaphyses. The rats in which tumor was implanted showed hypercalcemia, increased osteoclastic bone resorption, inhibition of bone formation with reduction in the bone apposition rate, and a loss in trabecular volume compared with the control rats. There was no evidence of tumor metastasis to bone. The results are consistent with the hypothesis that the Leydig cell tumor secretes a humoral factor capable of causing systemic bone resorption.

Original language	English (US)
Pages (from-to)	50-53
Number of pages	4
Journal	Metabolism
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/0026-0495(84)90161-6
State	Published - Jan 1984
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0026-0495(84)90161-6

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@article{e063d7b85f384359be352707286efdd3,

title = "Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors",

abstract = "The effect of Rice H-500 Leydig cell tumor tissue on bone in rats was assessed by morphometric analysis and tetracycline labeling of the lower femoral metaphyses. The rats in which tumor was implanted showed hypercalcemia, increased osteoclastic bone resorption, inhibition of bone formation with reduction in the bone apposition rate, and a loss in trabecular volume compared with the control rats. There was no evidence of tumor metastasis to bone. The results are consistent with the hypothesis that the Leydig cell tumor secretes a humoral factor capable of causing systemic bone resorption.",

author = "Tam, {Cherk S.} and Heersche, {Johan N.M.} and Arthur Santora and Spiegel, {Allen M.}",

note = "Funding Information: From the Departments of Pathology and Medicine and the MRC Group in Periodontal Physiology, University of Toronto, Onlario. Canada: and the Metabolic Diseases Branch, NIADDK. Bethesda, Maryland. Received for publication May 24, 1983. This work was supported by the MRC of Canada (Grant #MT 5917 and Group Grant in periodontal physiology). Address reprints requests to Dr Cherk S. Tam. The Queen Elizabeth Research Institute. 550 University Ave. Toronto, Ontario, Canada, M5G 2A2. 0 I984 by Grune & Stratton, Inc. 0026~495/84/330I4l008$01.00/0",

year = "1984",

month = jan,

doi = "10.1016/0026-0495(84)90161-6",

language = "English (US)",

volume = "33",

pages = "50--53",

journal = "Metabolism",

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T1 - Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors

AU - Tam, Cherk S.

AU - Heersche, Johan N.M.

AU - Santora, Arthur

AU - Spiegel, Allen M.

N1 - Funding Information: From the Departments of Pathology and Medicine and the MRC Group in Periodontal Physiology, University of Toronto, Onlario. Canada: and the Metabolic Diseases Branch, NIADDK. Bethesda, Maryland. Received for publication May 24, 1983. This work was supported by the MRC of Canada (Grant #MT 5917 and Group Grant in periodontal physiology). Address reprints requests to Dr Cherk S. Tam. The Queen Elizabeth Research Institute. 550 University Ave. Toronto, Ontario, Canada, M5G 2A2. 0 I984 by Grune & Stratton, Inc. 0026~495/84/330I4l008$01.00/0

PY - 1984/1

Y1 - 1984/1

N2 - The effect of Rice H-500 Leydig cell tumor tissue on bone in rats was assessed by morphometric analysis and tetracycline labeling of the lower femoral metaphyses. The rats in which tumor was implanted showed hypercalcemia, increased osteoclastic bone resorption, inhibition of bone formation with reduction in the bone apposition rate, and a loss in trabecular volume compared with the control rats. There was no evidence of tumor metastasis to bone. The results are consistent with the hypothesis that the Leydig cell tumor secretes a humoral factor capable of causing systemic bone resorption.

AB - The effect of Rice H-500 Leydig cell tumor tissue on bone in rats was assessed by morphometric analysis and tetracycline labeling of the lower femoral metaphyses. The rats in which tumor was implanted showed hypercalcemia, increased osteoclastic bone resorption, inhibition of bone formation with reduction in the bone apposition rate, and a loss in trabecular volume compared with the control rats. There was no evidence of tumor metastasis to bone. The results are consistent with the hypothesis that the Leydig cell tumor secretes a humoral factor capable of causing systemic bone resorption.

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JO - Metabolism

JF - Metabolism

IS - 1

ER -

Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors

Abstract

ASJC Scopus subject areas

UN SDGs

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