TY - JOUR
T1 - Skeletal muscle autophagy
T2 - A new metabolic regulator
AU - Neel, Brian A.
AU - Lin, Yuxi
AU - Pessin, Jeffrey E.
N1 - Funding Information:
We apologize that owing to space limitations we have been unable to cite many impactful studies. This work was supported by grants AR064420, DK033823, and AG23475 from the National Institutes of Health.
PY - 2013/12
Y1 - 2013/12
N2 - Autophagy classically functions as a physiological process to degrade cytoplasmic components, protein aggregates, and/or organelles, as a mechanism for nutrient breakdown, and as a regulator of cellular architecture. Proper autophagic flux is vital for both functional skeletal muscle, which controls the support and movement of the skeleton, and muscle metabolism. The role of autophagy as a metabolic regulator in muscle has been previously studied; however, the underlying molecular mechanisms that control autophagy in skeletal muscle have only recently begun to emerge. We review recent literature on the molecular pathways controlling skeletal muscle autophagy and discuss how they connect autophagy to metabolic regulation. We also focus on the implications these studies hold for understanding metabolic and muscle-wasting diseases.
AB - Autophagy classically functions as a physiological process to degrade cytoplasmic components, protein aggregates, and/or organelles, as a mechanism for nutrient breakdown, and as a regulator of cellular architecture. Proper autophagic flux is vital for both functional skeletal muscle, which controls the support and movement of the skeleton, and muscle metabolism. The role of autophagy as a metabolic regulator in muscle has been previously studied; however, the underlying molecular mechanisms that control autophagy in skeletal muscle have only recently begun to emerge. We review recent literature on the molecular pathways controlling skeletal muscle autophagy and discuss how they connect autophagy to metabolic regulation. We also focus on the implications these studies hold for understanding metabolic and muscle-wasting diseases.
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U2 - 10.1016/j.tem.2013.09.004
DO - 10.1016/j.tem.2013.09.004
M3 - Review article
C2 - 24182456
AN - SCOPUS:84888136964
SN - 1043-2760
VL - 24
SP - 635
EP - 643
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 12
ER -