TY - JOUR
T1 - Sinusitis and Atopy in Human Immunodeficiency Virus Infection
AU - Butkus Small, Catherine
AU - Kaufman, Alan
AU - Armenaka, Melina
AU - Rosenstreich, David L.
N1 - Funding Information:
Received 13 April 1992; revised II September 1992. Financial support: National Institutes of Health (AI-29871, CA-13330); The Henry and Lucy Moses Fund. Inc. (Montefiore Medical Center). Reprints or correspondence: Dr. Catherine Butkus Small. Division ofInfectious Diseases, Centennial 4. Montefiore Medical Center. III E. 21Oth S1.. Bronx, NY 10467.
PY - 1993/2
Y1 - 1993/2
N2 - Sinusitis is increased in patients with human immunodeficiency virus (HIV) infection. To determine the underlying mechanism(s), 37 HIV-positive patients were evaluated. HIV-negative controls included 21 with rhinosinusitis, 32 with atopy, and 16 without sinusitis. Twenty-two HIV-positive patients (59%) had sinusitis; 14 of them had AIDS. There wasa significant association between sinusitis severity and stage of HIV infection (P <.05). IgE levelswere higher in the HIV-positive patients, increased with disease progression, and were strongly correlated with sinusitis severity (P <.01). OfHIV-positive patients, 72% exhibited more than two positive skin tests compared with 24% of HIV-negative rhinosinusitis patients and 12.5% of controls (P <.05). Sinusitis is common in HIV-positive patients, especially those with AIDS. HIV causes an allergic diathesis with increased IgE levels and allergic reactivity. There is a significant correlation between IgE levels and sinusitis severity, suggesting sinusitis is part of this acquired atopic state.
AB - Sinusitis is increased in patients with human immunodeficiency virus (HIV) infection. To determine the underlying mechanism(s), 37 HIV-positive patients were evaluated. HIV-negative controls included 21 with rhinosinusitis, 32 with atopy, and 16 without sinusitis. Twenty-two HIV-positive patients (59%) had sinusitis; 14 of them had AIDS. There wasa significant association between sinusitis severity and stage of HIV infection (P <.05). IgE levelswere higher in the HIV-positive patients, increased with disease progression, and were strongly correlated with sinusitis severity (P <.01). OfHIV-positive patients, 72% exhibited more than two positive skin tests compared with 24% of HIV-negative rhinosinusitis patients and 12.5% of controls (P <.05). Sinusitis is common in HIV-positive patients, especially those with AIDS. HIV causes an allergic diathesis with increased IgE levels and allergic reactivity. There is a significant correlation between IgE levels and sinusitis severity, suggesting sinusitis is part of this acquired atopic state.
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U2 - 10.1093/infdis/167.2.283
DO - 10.1093/infdis/167.2.283
M3 - Article
C2 - 8421162
AN - SCOPUS:0027470999
SN - 0022-1899
VL - 167
SP - 283
EP - 290
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -