Sinonasal adenocarcinoma: A rare second malignancy in long term retinoblastoma survivors

Pooja Bhagia, Agnes Basas Colanta, David H. Abramson, Diane L. Carlson, Ruth A. Kleinerman, Dennis Kraus, Ira J. Dunkel

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Retinoblastoma is the most common primary cancer of the eye in children. The incidence of second tumors in survivors of bilateral retinoblastoma and in survivors of unilateral retinoblastoma who presumably carry a germline RB1 mutation is documented. This article describes the previously unrecognized association of sinonasal adenocarcinoma as a second malignancy in retinoblastoma survivors. We present three cases who received radiation therapy as a part of their treatment and developed sinonasal adenocarcinoma as a second malignancy. Sinonasal adenocarcinoma should be considered as a second malignancy in retinoblastoma survivors who present with vague sinus symptoms.

Original languageEnglish (US)
Pages (from-to)693-695
Number of pages3
JournalPediatric Blood and Cancer
Volume57
Issue number4
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Retinoblastoma
  • Second malignancy
  • Sinonasal adenocarcinoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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