Single-molecule insights into mRNA dynamics in neurons

Adina R. Buxbaum; Young J. Yoon; Robert H. Singer; Hye Yoon Park

doi:10.1016/j.tcb.2015.05.005

Single-molecule insights into mRNA dynamics in neurons

Adina R. Buxbaum, Young J. Yoon, Robert H. Singer, Hye Yoon Park

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.

Original language	English (US)
Pages (from-to)	468-475
Number of pages	8
Journal	Trends in Cell Biology
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/j.tcb.2015.05.005
State	Published - Aug 1 2015

Keywords

Local translation
RNA localization
mRNA tracking
smFISH

ASJC Scopus subject areas

Cell Biology

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10.1016/j.tcb.2015.05.005

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title = "Single-molecule insights into mRNA dynamics in neurons",

abstract = "Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.",

keywords = "Local translation, RNA localization, mRNA tracking, smFISH",

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AU - Buxbaum, Adina R.

AU - Yoon, Young J.

AU - Singer, Robert H.

AU - Park, Hye Yoon

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.

AB - Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.

KW - Local translation

KW - RNA localization

KW - mRNA tracking

KW - smFISH

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Single-molecule insights into mRNA dynamics in neurons

Abstract

Keywords

ASJC Scopus subject areas

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