Silicone allergy in ventriculoperitoneal shunts

David F. Jimenez, Robert Keating, James T. Goodrich

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Reported are the cases of three hydrocephalic patients who developed a clinically heterogenous entity with an allergic rejection of their silicone ventriculoperitoneal shunts. All of the patients had an original presentation indicative of a shunt infection, but laboratory analysis revealed sterile cerebrospinal fluid in all three cases. The typical course included recurrent skin breakdowns over the shunt tract, subsequent infections and development of fungating granulomas. Treatment, with successful resolution of the symptoms, included changing the shunt material from silicone to polyurethane, with immunosuppression in one patient and removal of the shunt altogether in the other two patients. The roles of the immune system and silicone in the pathophysiology of this condition are discussed.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalChild's Nervous System
Issue number1
StatePublished - Jan 1994
Externally publishedYes


  • Allergies
  • Rejection
  • Silicone
  • Ventriculoperitoneal shunts

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


Dive into the research topics of 'Silicone allergy in ventriculoperitoneal shunts'. Together they form a unique fingerprint.

Cite this