Signals, synapses, and synthesis: How new proteins control plasticity

R. Suzanne Zukin, Joel D. Richter, Claudia Bagni

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal regulation of gene expression and endow synapses with the capacity to autonomously alter their structure and function. Emerging evidence indicates that RNA binding proteins, ribosomes, translation factors and mRNAs encoding proteins critical to synaptic structure and function localize to neuronal processes. RNAs are transported into dendrites in a translationally quiescent state where they are activated by synaptic stimuli. Two RNA binding proteins that regulate dendritic RNA delivery and translational repression are cytoplasmic polyadenylation element binding protein and fragile X mental retardation protein (FMRP). The fragile X syndrome (FXS) is the most common known genetic cause of autism and is characterized by the loss of FMRP. Hallmark features of the FXS include dysregulation of spine morphogenesis and exaggerated metabotropic glutamate receptor-dependent long term depression, a cellular substrate of learning and memory. Current research focuses on mechanisms whereby mRNAs are transported in a translationally repressed state from soma to distal process and are activated at synaptic sites in response to synaptic signals.

Original languageEnglish (US)
Article number14
JournalFrontiers in Neural Circuits
Issue numberOCT
StatePublished - Oct 7 2009


  • CPEB
  • Cytoplasmic polyadenylation
  • FMRP
  • Fragile X syndrome
  • Synaptic plasticity
  • Synaptic signaling
  • Translational control

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Signals, synapses, and synthesis: How new proteins control plasticity'. Together they form a unique fingerprint.

Cite this