Short-term bone loss in HIV-infected premenopausal women

Michael T. Yin, Dalian Lu, Serge Cremers, Phyllis C. Tien, Mardge H. Cohen, Qiuhu Shi, Elizabeth Shane, Elizabeth T. Golub, Kathryn Anastos

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Background: Low bone mineral density (BMD) has been reported in HIV+ women, but less is known about the longitudinal evolution of BMD and fracture incidence. Methods: In 100 HIV+ and 68 HIV-premenopausal women in the Women's Interagency HIV Study, BMD was measured by dual energy X-ray absorptiometry at the femoral neck (FN) and lumbar spine (LS) at index visit and after a median of 2.5 years. Results: In HIV+ women, BMD at index visit was normal but 5% lower at the LS and FN than in HIV-women. Annual percent decrease in BMD did not differ between HIV+ and HIV-women at the LS (-0.8% ± 0.2% vs-0.4% ± 0.2%, P = 0.20) or FN (-0.8% ± 0.3% vs-0.6% ± 0.3%, P = 0.56) and remained similar after adjustment for age, weight, and BMD at index visit. Among HIV+ women, bone loss was associated with vitamin D deficiency and opiate use but not with use or class of antiretrovirals. Incidence of self-reported fracture was 0.74 per 100 person-years in HIV+ women and similar in HIV-women. Conclusions: In premenopausal HIV+ women, index BMD was lower than comparable HIV-women; however, rates of bone loss at the LS and FN were similar over 2.5 years of observation, irrespective of antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number2
StatePublished - Feb 2010


  • Bone density
  • Bone loss
  • Bone turnover markers
  • HIV
  • Osteoporosis
  • Premenopausal women

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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